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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLK1
All Species:
34.55
Human Site:
S592
Identified Species:
47.5
UniProt:
P53350
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53350
NP_005021.2
603
68255
S592
T
M
V
D
K
L
L
S
S
R
S
A
S
N
R
Chimpanzee
Pan troglodytes
XP_001163623
603
68223
S592
T
M
V
D
K
L
L
S
S
R
S
A
S
N
R
Rhesus Macaque
Macaca mulatta
XP_001092070
603
68240
S592
T
M
V
D
K
L
L
S
S
R
S
A
S
N
R
Dog
Lupus familis
XP_547091
832
93293
S820
T
M
V
D
K
L
L
S
S
R
S
A
A
N
R
Cat
Felis silvestris
Mouse
Mus musculus
Q07832
603
68282
S592
T
M
V
D
K
L
L
S
S
R
S
A
S
N
R
Rat
Rattus norvegicus
Q62673
603
68295
S592
T
M
V
D
K
L
L
S
S
R
S
A
C
N
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505317
482
55166
K472
V
D
K
L
L
S
S
K
S
A
G
A
R
L
K
Chicken
Gallus gallus
NP_001025810
595
66904
S583
T
M
V
E
K
L
L
S
S
K
S
G
S
A
R
Frog
Xenopus laevis
P70032
598
68193
S586
T
M
V
E
K
L
Q
S
S
K
S
A
V
A
H
Zebra Danio
Brachydanio rerio
NP_001003890
595
67743
A583
N
M
V
E
K
L
M
A
C
K
S
S
T
T
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52304
576
66955
V552
S
T
I
V
E
N
G
V
S
K
D
L
Y
Q
K
Honey Bee
Apis mellifera
XP_396707
575
66141
K564
N
L
A
Y
A
H
E
K
L
V
L
M
L
S
N
Nematode Worm
Caenorhab. elegans
P34331
649
73615
S597
T
M
I
E
R
L
M
S
D
A
N
V
V
S
Q
Sea Urchin
Strong. purpuratus
XP_784826
587
66895
D573
N
M
V
K
N
M
L
D
K
K
T
T
T
T
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P0C8M8
626
70215
T614
N
S
E
N
K
Q
V
T
Y
V
A
R
K
E
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STV4
445
50410
N435
P
P
D
A
S
M
R
N
R
V
T
K
A
K
S
Baker's Yeast
Sacchar. cerevisiae
P32562
705
81013
L695
L
T
L
I
K
E
G
L
K
Q
K
S
T
I
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.8
69.5
N.A.
95
94.1
N.A.
69.3
80
79.7
74.3
N.A.
50.7
51.4
49.9
59.3
Protein Similarity:
100
99.8
99.8
71
N.A.
97.6
96.8
N.A.
74.7
89.8
90.5
87.5
N.A.
69.4
69.9
66.2
76.4
P-Site Identity:
100
100
100
93.3
N.A.
100
93.3
N.A.
13.3
73.3
60
33.3
N.A.
6.6
0
26.6
20
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
20
86.6
73.3
73.3
N.A.
40
13.3
73.3
46.6
Percent
Protein Identity:
N.A.
31.7
N.A.
26
33.9
N.A.
Protein Similarity:
N.A.
50.1
N.A.
40.4
51.6
N.A.
P-Site Identity:
N.A.
6.6
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
26.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
6
6
6
0
0
6
0
12
6
48
12
12
6
% A
% Cys:
0
0
0
0
0
0
0
0
6
0
0
0
6
0
0
% C
% Asp:
0
6
6
36
0
0
0
6
6
0
6
0
0
0
0
% D
% Glu:
0
0
6
24
6
6
6
0
0
0
0
0
0
6
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
12
0
0
0
6
6
0
0
0
% G
% His:
0
0
0
0
0
6
0
0
0
0
0
0
0
0
6
% H
% Ile:
0
0
12
6
0
0
0
0
0
0
0
0
0
6
0
% I
% Lys:
0
0
6
6
65
0
0
12
12
30
6
6
6
6
12
% K
% Leu:
6
6
6
6
6
59
48
6
6
0
6
6
6
6
0
% L
% Met:
0
65
0
0
0
12
12
0
0
0
0
6
0
0
0
% M
% Asn:
24
0
0
6
6
6
0
6
0
0
6
0
0
36
6
% N
% Pro:
6
6
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
6
6
0
0
6
0
0
0
6
6
% Q
% Arg:
0
0
0
0
6
0
6
0
6
36
0
6
6
0
42
% R
% Ser:
6
6
0
0
6
6
6
53
59
0
53
12
30
12
6
% S
% Thr:
53
12
0
0
0
0
0
6
0
0
12
6
18
12
12
% T
% Val:
6
0
59
6
0
0
6
6
0
18
0
6
12
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
6
0
0
0
0
6
0
0
0
6
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _